Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, et al. Immediate or delayed dissection of regional nodes in patients with melanoma of the trunk: a randomised trial. 2019 17(4):367–402.Ĭascinelli N, Morabito A, Santinami M, MacKie RM, Belli F. Cutaneous melanoma, version 2.2019, NCCN clinical practice guidelines in oncology. 563–85.Ĭoit DG, Thompson JA, Albertini MR, Barker C, Carson WE, Contreras C, et al. In: Amin MBES, Greene F, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, Jessup JM, Brierley JD, Gaspar LE, Schilsky RL, Balch CM, Winchester DP, Asare DA, Madera M, Gress DM, Meyer LR, editors. ![]() The rationale for sentinel-node biopsy in primary melanoma. Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases. Papers of particular interest, published recently, have been highlighted as: īalch CM, Gershenwald JE, Soong SJ, Thompson JF, Ding S, Byrd DR, et al. SLNB continues to play a crucial role in the management of patients with melanoma, allowing for risk stratification, potential regional disease control, and further treatment options for patients with a positive SLN. Treatment options for patients with SLN metastases now include surveillance, completion lymph node dissection, and adjuvant therapy with checkpoint inhibitors and targeted therapy. Finally, the management of patients with a positive sentinel lymph node (SLN) has undergone dramatic changes over the past several years based on the results of recent important clinical trials. ![]() Furthermore, there have been technical advances in the SLNB technique, such as the development of newer radiotracers and use of SPECT/CT, and there is some data to suggest performing a SLNB may be therapeutic. However, SLNB also has an important role in the management of patients with other subtypes of melanoma such as thick melanomas, certain thin melanomas, and specific histologic variants of melanoma such as desmoplastic melanoma. The vast majority of patients newly diagnosed with melanoma present with clinically localized disease, and sentinel lymph node biopsy (SLNB) is a standard of care in the management of these patients, particularly in intermediate thickness cases, in order to provide important prognostic data.
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